A research about the risk of thyroid function test on preterm birth was conducted by researchers at the Academic Center for Thyroid Diseases at Erasmus Medical Center in Rotterdam, the Netherlands, based on information of the Ovid MEDLINE, EMBASE, Web of Science, the Cochrane Central Rgistrar of Controlled Trials, and Google Scholar databases.
The study was done on about 47,045 women, with subclinical hypothyroidism, isolated hypothyroxinemia, and thyroid peroxidase antibody positivity, and these all were significantly associated with a higher risk of preterm birth. This proves that all of these conditions are risk factors for preterm birth.
When the results came up, it was found that the risk of preterm birth was higher for women with subclinical hypothyroidism than euthyroid women. Among women with isolated hypothyroxinemia, the risk of preterm birth was 7.1% vs 5.0% in euthyroid women. In continuous analyses, each 1-SD higher maternal thyrotropin concentration was associated with a higher risk of preterm birth. Thyroid peroxidase antibody – positive women had a higher risk of preterm birth vs TOP antibody – negative women.
These results provide insights toward optimizing clinical decision-making strategies that should consider the potential harms and benefits of screening programs and levothyroxine treatment during pregnancy.
Source: Jama Network
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